Maddrey’s Discriminant Function

Maddrey’s discriminant function for alcoholic hepatitis suggests which patients with alcoholic hepatitis may have a poor prognosis and benefit from steroid administration. This tool was created by Dr. Willis Maddrey. Dr. Maddrey is professor of internal medicine at The University of Texas Southwestern Medical Center at Dallas. Previously, he directed the liver unit at The Johns Hopkins University School of Medicine and was chairman of the Department of Medicine at Jefferson Medical College.¹

https://www.mdcalc.com/maddreys-discriminant-function-alcoholic-hepatitis

In a meta-analysis of 4 controlled trials, we found corticosteroid use to reduce risk of death within 28 days of treatment, but not in the following 6 months. This loss of efficacy over time indicates a need for new therapeutic strategies to improve medium-term outcomes.²

F o r m o r e i n f o r m a t i o n about the above study meta-analysis , p l e a s e v i s i t https://pubmed.ncbi.nlm.nih.gov/29738698/

References: 1. https://www.mdcalc.com/maddreys-discriminant-function-alcoholic-hepatitis

2. Louvet A, Thursz MR, Kim DJ, Labreuche J, Atkinson SR, Sidhu SS, O’Grady JG, Akriviadis E, Sinakos E, Carithers RL Jr, Ramond MJ, Maddrey WC, Morgan TR, Duhamel A, Mathurin P. Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo-a Meta-analysis of Individual Data From Controlled Trials. Gastroenterology. 2018 Aug;155(2):458-468.e8. doi: 10.1053/j.gastro.2018.05.011. Epub 2018 May 5. PMID: 29738698.

Disclaimer: The information provided on this website is for informational purposes only and is not intended to take the place of consultation with your physician.